About the Role

As a Vice President/Principal on our Investment & Research team in either San Francisco, CA or New York, NY, you will lead investments in a specific breakout category of either developer tools, infrastructure software, AI/ML and/or deep tech. Your passion for technology, startups, and investing will be instrumental as you work on our Investment & Research team to identify, diligence, and invest in exceptional early-stage companies that have the potential to achieve significant scale.

For eleven years, 645 Ventures has been at the forefront of innovation in venture capital. As a software-powered firm, our proprietary platform, Voyager, supports all aspects of the investment lifecycle—from sourcing and due diligence to portfolio monitoring and collaboration. Our tools allow us to make data-informed decisions, scale our sourcing efforts, and operate efficiently as a modern venture firm.

We are looking for an individual who has a passion for early-stage startup investing and venture capital, paired with a strong engineering knowledge/background. You will focus on the firm’s developer tools and infrastructure investment and/or deep tech practice while working closely with the firm’s founders and existing team members across the entire organization.

Responsibilities may include, but are not limited to:

• Investment Strategy: Help build and expand the firm’s investment strategy in the areas of Infrastructure Software and Developer Tools and/or Deep Tech, positioning us to establish a leading practice over several years that will allow us to identify, invest in, and support early-stage companies that can become large publicly traded companies and/or M&A targets. Identify the market and technological trends that will drive the expansion of these companies, and assist our firm in refining its investment strategy to capitalize on the top companies benefiting from these trends.
• Deal Management, Evaluation, and Winning: Focus and expand the firm’s capacity to research, source and evaluate the high potential investments by organizing sourcing and screening initiatives, leading due diligence, as well as leveraging both internal software and the firm’s networks to surface high-quality deals. Collaborate with the Partners to negotiate, structure, and win deals. Collaborate with the General Partners to negotiate, structure, and win deals.
• Relationship Building: Deepen relationships with top seed and early-stage investors, founders, accelerators, portfolio companies, universities, and other venture capital firms.
• 645 Thought Leadership: Support the ideation, design, execution and promotion of content authored by 645 for both our website and external publishing platforms, including securing contributor placements in media publications. Present at conferences, produce a podcast, host events, or publish your ideas on engineering and technology investing concepts. Be a leader among and valuable contributor to the community.

Skills and Experience Requirements:

• We are prioritizing at least 3-5 years of Venture Capital experience in developer tools, infrastructure, AI/ML and/or deep tech, where you have invested in companies that have achieved considerable growth or successful exits.
• Proven ability to build deep relationships in the startup community among exceptional founders, technologists, venture capitalists, and others who are on the cutting edge of innovation and startup formation.
• Ability to translate technical and operational skills to strong investment acumen over the long term, including in categories such as venture capital valuation, market assessment, and negotiating deal terms.
• Up-to-date technical knowledge and passion for staying recent on the modern infrastructure stack including an understanding of the open-source ecosystem.
• Strong communication abilities, including proficiency in written communication, interpersonal interactions, and public speaking.
• Ability to listen, understand, connect and build strong relationships.
• A history of angel investing or access to an exceptional network of technical startup founders
• Experience providing technical due diligence for investment or M&A
• Responsible, responsive, communicative, and transparent.
• Energetic,self-motivated, and achievement-oriented. Capable of working independently as a self-starter.
• Highly organized with strong time and project management skills, adept at managing several projects simultaneously within strict time constraints.
• Ability to execute sizable projects from start to finish.

About 645 Ventures

At 645 Ventures, we help founders bring the invisible to life. With over $550 million in assets under management, our nine-year-old firm is expanding rapidly, backed by leading institutional investors, including the world's best university endowments, funds of funds, and pension funds.

Our goal is to back founders who aspire to build iconic businesses that transform industries and reach large scale M&A and IPO events. We are proud to have invested in several companies already advancing along that trajectory, including FiscalNote (IPO: NOTE), Goldbelly, Iterable, Overtime, Resident, Eden Health and Solidus Labs. We have over 70 active companies in our portfolio and typically invest between

$1 million - $15 million as lead investors or alongside other top-tier funds. Our portfolio spans enterprise SaaS, infrastructure software, and consumer technology.

We have offices in both New York City & South Park, San Francisco. We have built a team and culture that is inclusive, collaborative, and which prioritizes a client-service mindset. 645 is deeply committed to diversity, equity and inclusion—and our team and community reflect that commitment.