Executive Assistant/Office Manager - SF

645 Ventures
645 Ventures

Operations · Full-time

San Francisco, CA, USA

Posted on Nov 4, 2026

About the Role

We’re looking for an Executive Assistant/Office Manager to join our team in San Francisco. This individual will provide high-level administrative support to our SF based Investment Partner and other 645 leaders, manage the general administration of our San Francisco (in-person) office, and help keep the 645 brand visible through events and social media. Ideally, this person has previous experience running an office environment, organizing and coordinating everything from calendars to dinners to 100-person events, and has a passion for putting a smile on people’s faces.

By contributing to the firm’s constantly increasing standard of excellence, this role will have a tremendous impact on our team. We work best with people who are collaborative, versatile, curious, hard-working and always ready to pitch in.

Location: South Park, San Francisco office, Monday through Friday

Responsibilities may include (but not limited to):

Executive Support

•       Meticulous calendar management for the Managing Partner, including planning meetings, coordinating recurring check-ins and communicating with multiple parties to schedule meetings and team dinners

•       Own the Investment Committee (IC) and Mini IC calendar, board meeting scheduling, and recurring portfolio company syncs

•       Support calendar management and coordination for Investment & Research founder meetings, operating with a high degree of responsiveness

•       Book travel, as well as calendaring and travel coordination for team members (as needed)

•       Serve as a professional point of contact for founders, LPs and partners

SF Office Management

•       Greet visitors and host founders, candidates and guests

•       Coordinate with portfolio companies visiting or working from the SF office

•       Handle maintenance requests, office access, mail, daily lunch orders for the team, and logistics such as office supplies, food and snacks

•       Manage landlord and vendor relationships, including IT, AV and office build-out projects

•       Procure and set up computers and equipment for new hires

•       Track office spend in Ramp and support quarterly expense tagging

•       Help design and bring the firm’s culture to the office space, ensuring the highest and most efficient use by team members, founders, and guests

Events

•       Own event logistics and coordination for events at the SF office and around the Bay Area, including founder dinners, hackathons, campus events and in-office gatherings

•       Source venues, gather and negotiate quotes, manage guest lists and headcounts, prepare printed materials (name tags, table tents) and run day-of setup

Communications & Content

•       Draft and publish posts on 645’s LinkedIn and X accounts, including portfolio company announcements and event recaps, in partnership with the investment team

•       Write and send the weekly internal team newsletter

Skills and Experience Requirements:

•       You have 3-5 years of experience in an Office Manager/Coordinator or Executive Assistant role within a VC or financial services environment (PE/VC experience preferred)

•       Proven experience managing the calendar of a senior executive

•       Event planning experience, from intimate 15-person dinners to 100+ person events

•       Strong writer, comfortable drafting social media posts and internal communications in the firm’s voice

•       Experience working with Excel and Google Sheets; proficiency with Google Workspace, Slack and Zoom (Airtable, Ramp and Canva a plus)

•       Highly responsible, responsive, reliable, communicative and transparent

•       Very high level of energy, highly self-motivated, and a passion for success

•       Excellent ability to listen, understand, connect and build strong relationships

•       Highly organized with incredible time and project management, team coordination and strong ability to multitask

•       Proven ability to thrive under tight deadlines while successfully juggling a multitude of projects simultaneously, including across time zones

•       Ability to work independently; a self-starter who can run robust projects from beginning to end, including technology set ups in the office

•       Sound judgment and discretion with confidential information

•       Very strong communication skills, both written and verbal

Nice to Have

•       Familiarity with the Bay Area startup and university ecosystem (e.g., Stanford, Berkeley)

About 645 Ventures

At 645 Ventures, we help founders bring the invisible to life. With over $550 million in assets under management, our ten-year-old firm is expanding rapidly, backed by leading institutional investors, including the world's best university endowments, funds of funds, and pension funds.

Our goal is to back founders who aspire to build iconic businesses that transform industries and reach large scale M&A and IPO events. We are proud to have invested in several companies already advancing along that trajectory, including Goldbelly, Iterable, Overtime, Resident, Setpoint and Shift5. We have over 60 active companies in our portfolio and typically invest between $1 million - $15 million as lead investors or alongside other top-tier funds. Our portfolio spans enterprise SaaS, infrastructure software, and consumer technology.

We have built a team and culture that is inclusive, collaborative, and prioritizes a client-service mindset. 645 is deeply committed to diversity, equity, and inclusion—and our team and community reflect that commitment.

645 Ventures is an equal opportunity employer

645 Ventures is an equal opportunity employer.